Colonic inflammation in Parkinson's disease.
Identifieur interne : 000D53 ( Main/Exploration ); précédent : 000D52; suivant : 000D54Colonic inflammation in Parkinson's disease.
Auteurs : David Devos [France] ; Thibaud Lebouvier ; Bernard Lardeux ; Mandy Biraud ; Tiphaine Rouaud ; Hélène Pouclet ; Emmanuel Coron ; Stanislas Bruley Des Varannes ; Philippe Naveilhan ; Jean-Michel Nguyen ; Michel Neunlist ; Pascal DerkinderenSource :
- Neurobiology of disease [ 1095-953X ] ; 2013.
English descriptors
- KwdEn :
- Adult, Aged, Colitis (etiology), Colitis (immunology), Colitis (pathology), Cytokines (biosynthesis), Female, Humans, Inflammation (etiology), Inflammation (immunology), Inflammation (pathology), Lewy Bodies (pathology), Male, Middle Aged, Parkinson Disease (complications), Parkinson Disease (immunology), Parkinson Disease (pathology), RNA, Messenger (analysis), Real-Time Polymerase Chain Reaction.
- MESH :
- chemical , analysis : RNA, Messenger.
- chemical , biosynthesis : Cytokines.
- complications : Parkinson Disease.
- etiology : Colitis, Inflammation.
- immunology : Colitis, Inflammation, Parkinson Disease.
- pathology : Colitis, Inflammation, Lewy Bodies, Parkinson Disease.
- Adult, Aged, Female, Humans, Male, Middle Aged, Real-Time Polymerase Chain Reaction.
Abstract
Lewy pathology affects the gastrointestinal tract in Parkinson's disease (PD) and data from recent genetic studies suggest a link between PD and gut inflammation. We therefore undertook the present survey to investigate whether gastrointestinal inflammation occurs in PD patients. Nineteen PD patients and 14 age-matched healthy controls were included. For each PD patients, neurological and gastrointestinal symptoms were assessed using the Unified Parkinson's Disease Rating Scale part III and the Rome III questionnaire, respectively and cumulative lifetime dose of L-dopa was calculated. Four biopsies were taken from the ascending colon during the course of a total colonoscopy in controls and PD patients. The mRNA expression levels of pro-inflammatory cytokines (tumor necrosis factor alpha, interferon gamma, interleukin-6 and interleukin-1 beta) and glial marker (Glial fibrillary acidic protein, Sox-10 and S100-beta) were analyzed using real-time PCR in two-pooled biopsies. Immunohistochemical analysis was performed on the two remaining biopsies using antibodies against phosphorylated alpha-synuclein to detect Lewy pathology. The mRNA expression levels of pro-inflammatory cytokines as well as of two glial markers (Glial fibrillary acidic protein and Sox-10) were significantly elevated in the ascending colon of PD patients with respect to controls. The levels of tumor necrosis factor alpha, interferon gamma, interleukin-6, interleukin-1 beta and Sox-10 were negatively correlated with disease duration. By contrast, no correlations were found between the levels of pro-inflammatory cytokines or glial markers and disease severity, gastrointestinal symptoms or cumulative lifetime dose of L-dopa. There was no significant difference in the expression of pro-inflammatory cytokines or glial marker between patients with and without enteric Lewy pathology. Our findings provide evidence that enteric inflammation occurs in PD and further reinforce the role of peripheral inflammation in the initiation and/or the progression of the disease.
DOI: 10.1016/j.nbd.2012.09.007
PubMed: 23017648
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000779
- to stream PubMed, to step Curation: 000746
- to stream PubMed, to step Checkpoint: 000746
- to stream Ncbi, to step Merge: 000F88
- to stream Ncbi, to step Curation: 000F88
- to stream Ncbi, to step Checkpoint: 000F88
- to stream Main, to step Merge: 000D79
- to stream Main, to step Curation: 000D53
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Colonic inflammation in Parkinson's disease.</title><author><name sortKey="Devos, David" sort="Devos, David" uniqKey="Devos D" first="David" last="Devos">David Devos</name><affiliation wicri:level="3"><nlm:affiliation>Inserm, U913, Nantes, F-44093, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Inserm, U913, Nantes, F-44093</wicri:regionArea><placeName><region type="region" nuts="2">Pays de la Loire</region></placeName></affiliation></author><author><name sortKey="Lebouvier, Thibaud" sort="Lebouvier, Thibaud" uniqKey="Lebouvier T" first="Thibaud" last="Lebouvier">Thibaud Lebouvier</name></author><author><name sortKey="Lardeux, Bernard" sort="Lardeux, Bernard" uniqKey="Lardeux B" first="Bernard" last="Lardeux">Bernard Lardeux</name></author><author><name sortKey="Biraud, Mandy" sort="Biraud, Mandy" uniqKey="Biraud M" first="Mandy" last="Biraud">Mandy Biraud</name></author><author><name sortKey="Rouaud, Tiphaine" sort="Rouaud, Tiphaine" uniqKey="Rouaud T" first="Tiphaine" last="Rouaud">Tiphaine Rouaud</name></author><author><name sortKey="Pouclet, Helene" sort="Pouclet, Helene" uniqKey="Pouclet H" first="Hélène" last="Pouclet">Hélène Pouclet</name></author><author><name sortKey="Coron, Emmanuel" sort="Coron, Emmanuel" uniqKey="Coron E" first="Emmanuel" last="Coron">Emmanuel Coron</name></author><author><name sortKey="Bruley Des Varannes, Stanislas" sort="Bruley Des Varannes, Stanislas" uniqKey="Bruley Des Varannes S" first="Stanislas" last="Bruley Des Varannes">Stanislas Bruley Des Varannes</name></author><author><name sortKey="Naveilhan, Philippe" sort="Naveilhan, Philippe" uniqKey="Naveilhan P" first="Philippe" last="Naveilhan">Philippe Naveilhan</name></author><author><name sortKey="Nguyen, Jean Michel" sort="Nguyen, Jean Michel" uniqKey="Nguyen J" first="Jean-Michel" last="Nguyen">Jean-Michel Nguyen</name></author><author><name sortKey="Neunlist, Michel" sort="Neunlist, Michel" uniqKey="Neunlist M" first="Michel" last="Neunlist">Michel Neunlist</name></author><author><name sortKey="Derkinderen, Pascal" sort="Derkinderen, Pascal" uniqKey="Derkinderen P" first="Pascal" last="Derkinderen">Pascal Derkinderen</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="RBID">pubmed:23017648</idno><idno type="pmid">23017648</idno><idno type="doi">10.1016/j.nbd.2012.09.007</idno><idno type="wicri:Area/PubMed/Corpus">000779</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000779</idno><idno type="wicri:Area/PubMed/Curation">000746</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000746</idno><idno type="wicri:Area/PubMed/Checkpoint">000746</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000746</idno><idno type="wicri:Area/Ncbi/Merge">000F88</idno><idno type="wicri:Area/Ncbi/Curation">000F88</idno><idno type="wicri:Area/Ncbi/Checkpoint">000F88</idno><idno type="wicri:Area/Main/Merge">000D79</idno><idno type="wicri:Area/Main/Curation">000D53</idno><idno type="wicri:Area/Main/Exploration">000D53</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Colonic inflammation in Parkinson's disease.</title><author><name sortKey="Devos, David" sort="Devos, David" uniqKey="Devos D" first="David" last="Devos">David Devos</name><affiliation wicri:level="3"><nlm:affiliation>Inserm, U913, Nantes, F-44093, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Inserm, U913, Nantes, F-44093</wicri:regionArea><placeName><region type="region" nuts="2">Pays de la Loire</region></placeName></affiliation></author><author><name sortKey="Lebouvier, Thibaud" sort="Lebouvier, Thibaud" uniqKey="Lebouvier T" first="Thibaud" last="Lebouvier">Thibaud Lebouvier</name></author><author><name sortKey="Lardeux, Bernard" sort="Lardeux, Bernard" uniqKey="Lardeux B" first="Bernard" last="Lardeux">Bernard Lardeux</name></author><author><name sortKey="Biraud, Mandy" sort="Biraud, Mandy" uniqKey="Biraud M" first="Mandy" last="Biraud">Mandy Biraud</name></author><author><name sortKey="Rouaud, Tiphaine" sort="Rouaud, Tiphaine" uniqKey="Rouaud T" first="Tiphaine" last="Rouaud">Tiphaine Rouaud</name></author><author><name sortKey="Pouclet, Helene" sort="Pouclet, Helene" uniqKey="Pouclet H" first="Hélène" last="Pouclet">Hélène Pouclet</name></author><author><name sortKey="Coron, Emmanuel" sort="Coron, Emmanuel" uniqKey="Coron E" first="Emmanuel" last="Coron">Emmanuel Coron</name></author><author><name sortKey="Bruley Des Varannes, Stanislas" sort="Bruley Des Varannes, Stanislas" uniqKey="Bruley Des Varannes S" first="Stanislas" last="Bruley Des Varannes">Stanislas Bruley Des Varannes</name></author><author><name sortKey="Naveilhan, Philippe" sort="Naveilhan, Philippe" uniqKey="Naveilhan P" first="Philippe" last="Naveilhan">Philippe Naveilhan</name></author><author><name sortKey="Nguyen, Jean Michel" sort="Nguyen, Jean Michel" uniqKey="Nguyen J" first="Jean-Michel" last="Nguyen">Jean-Michel Nguyen</name></author><author><name sortKey="Neunlist, Michel" sort="Neunlist, Michel" uniqKey="Neunlist M" first="Michel" last="Neunlist">Michel Neunlist</name></author><author><name sortKey="Derkinderen, Pascal" sort="Derkinderen, Pascal" uniqKey="Derkinderen P" first="Pascal" last="Derkinderen">Pascal Derkinderen</name></author></analytic><series><title level="j">Neurobiology of disease</title><idno type="eISSN">1095-953X</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Colitis (etiology)</term><term>Colitis (immunology)</term><term>Colitis (pathology)</term><term>Cytokines (biosynthesis)</term><term>Female</term><term>Humans</term><term>Inflammation (etiology)</term><term>Inflammation (immunology)</term><term>Inflammation (pathology)</term><term>Lewy Bodies (pathology)</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (immunology)</term><term>Parkinson Disease (pathology)</term><term>RNA, Messenger (analysis)</term><term>Real-Time Polymerase Chain Reaction</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>RNA, Messenger</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Cytokines</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Colitis</term><term>Inflammation</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Colitis</term><term>Inflammation</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Colitis</term><term>Inflammation</term><term>Lewy Bodies</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Real-Time Polymerase Chain Reaction</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Lewy pathology affects the gastrointestinal tract in Parkinson's disease (PD) and data from recent genetic studies suggest a link between PD and gut inflammation. We therefore undertook the present survey to investigate whether gastrointestinal inflammation occurs in PD patients. Nineteen PD patients and 14 age-matched healthy controls were included. For each PD patients, neurological and gastrointestinal symptoms were assessed using the Unified Parkinson's Disease Rating Scale part III and the Rome III questionnaire, respectively and cumulative lifetime dose of L-dopa was calculated. Four biopsies were taken from the ascending colon during the course of a total colonoscopy in controls and PD patients. The mRNA expression levels of pro-inflammatory cytokines (tumor necrosis factor alpha, interferon gamma, interleukin-6 and interleukin-1 beta) and glial marker (Glial fibrillary acidic protein, Sox-10 and S100-beta) were analyzed using real-time PCR in two-pooled biopsies. Immunohistochemical analysis was performed on the two remaining biopsies using antibodies against phosphorylated alpha-synuclein to detect Lewy pathology. The mRNA expression levels of pro-inflammatory cytokines as well as of two glial markers (Glial fibrillary acidic protein and Sox-10) were significantly elevated in the ascending colon of PD patients with respect to controls. The levels of tumor necrosis factor alpha, interferon gamma, interleukin-6, interleukin-1 beta and Sox-10 were negatively correlated with disease duration. By contrast, no correlations were found between the levels of pro-inflammatory cytokines or glial markers and disease severity, gastrointestinal symptoms or cumulative lifetime dose of L-dopa. There was no significant difference in the expression of pro-inflammatory cytokines or glial marker between patients with and without enteric Lewy pathology. Our findings provide evidence that enteric inflammation occurs in PD and further reinforce the role of peripheral inflammation in the initiation and/or the progression of the disease.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Pays de la Loire</li></region></list><tree><noCountry><name sortKey="Biraud, Mandy" sort="Biraud, Mandy" uniqKey="Biraud M" first="Mandy" last="Biraud">Mandy Biraud</name><name sortKey="Bruley Des Varannes, Stanislas" sort="Bruley Des Varannes, Stanislas" uniqKey="Bruley Des Varannes S" first="Stanislas" last="Bruley Des Varannes">Stanislas Bruley Des Varannes</name><name sortKey="Coron, Emmanuel" sort="Coron, Emmanuel" uniqKey="Coron E" first="Emmanuel" last="Coron">Emmanuel Coron</name><name sortKey="Derkinderen, Pascal" sort="Derkinderen, Pascal" uniqKey="Derkinderen P" first="Pascal" last="Derkinderen">Pascal Derkinderen</name><name sortKey="Lardeux, Bernard" sort="Lardeux, Bernard" uniqKey="Lardeux B" first="Bernard" last="Lardeux">Bernard Lardeux</name><name sortKey="Lebouvier, Thibaud" sort="Lebouvier, Thibaud" uniqKey="Lebouvier T" first="Thibaud" last="Lebouvier">Thibaud Lebouvier</name><name sortKey="Naveilhan, Philippe" sort="Naveilhan, Philippe" uniqKey="Naveilhan P" first="Philippe" last="Naveilhan">Philippe Naveilhan</name><name sortKey="Neunlist, Michel" sort="Neunlist, Michel" uniqKey="Neunlist M" first="Michel" last="Neunlist">Michel Neunlist</name><name sortKey="Nguyen, Jean Michel" sort="Nguyen, Jean Michel" uniqKey="Nguyen J" first="Jean-Michel" last="Nguyen">Jean-Michel Nguyen</name><name sortKey="Pouclet, Helene" sort="Pouclet, Helene" uniqKey="Pouclet H" first="Hélène" last="Pouclet">Hélène Pouclet</name><name sortKey="Rouaud, Tiphaine" sort="Rouaud, Tiphaine" uniqKey="Rouaud T" first="Tiphaine" last="Rouaud">Tiphaine Rouaud</name></noCountry><country name="France"><region name="Pays de la Loire"><name sortKey="Devos, David" sort="Devos, David" uniqKey="Devos D" first="David" last="Devos">David Devos</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000D53 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000D53 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonFranceV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:23017648
|texte= Colonic inflammation in Parkinson's disease.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:23017648" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonFranceV1
| This area was generated with Dilib version V0.6.29. |  |